ABSTRACT
We present a case of a young male with a five year history of a hair-loss patch presenting linear distribution on the scalp. A biopsy specimen revealed a lymphocytic panniculitis and fat degeneration with mucin deposit. Focal hydropic degeneration of basal cells was also evident. Direct immuno-fluorescence revealed peribulbar granular deposits of IgM, IgA and C3. Antinuclear antibody was negative. Clinical appearance was unusual but histological examination revealed linear lupus erythematosus profundus. To our knowledge, only one other case of linear lupus erythematosus profundus on the scalp has been reported in English written literature until now.
Subject(s)
Humans , Male , Alopecia , Antibodies, Antinuclear , Biopsy , Immunoglobulin A , Immunoglobulin M , Mucins , Panniculitis , Panniculitis, Lupus Erythematosus , ScalpABSTRACT
Microscopic polyangiitis (MPA) is a systemic vasculitis that is histologically characterized by small vessel involvement. Although MPA is primarily associated with necrotizing and crescentric glomerulonephritis and pulmonary capillaritis, MPA often has cutaneous features. We report a case of microscopic polyangiitis with acral necrosis as the skin manifestation. A 56-year-old man presented with acral dry gangrene on tip of finger and toe and reticulated erythema on leg. He had suffered from proteinuria, hemoptysis, and arthralgia. Histopathologically, small vessel vasculitis without granuloma was seen. A high serum level of pANCA was detected by ELISA. This is a relatively rare disease, which has a poor prognosis in the absence of aggressive therapy, and is infrequently reported in dermatologic journals in Korea.
Subject(s)
Humans , Middle Aged , Antibodies, Antineutrophil Cytoplasmic , Arthralgia , Enzyme-Linked Immunosorbent Assay , Erythema , Fingers , Gangrene , Glomerulonephritis , Granuloma , Hemoptysis , Korea , Leg , Microscopic Polyangiitis , Necrosis , Prognosis , Proteinuria , Rare Diseases , Skin Manifestations , Skin , Systemic Vasculitis , Toes , VasculitisABSTRACT
The beneficial effects of cyclosporine in severe chronic urticaria are well described. A 20-year-old woman suffered from chronic urticaria for 3 years, had been treated with oral antihistamines and glucocorticoids, but her symptoms were uncontrolled. Laboratory examination including eosinophil count, IgE total value, complement level, anti-nuclear antibodies, hepatic, and renal function test and esophagogastroscopic study, revealed no abnormalities. Since she was treated with cyclosporine 6mg/kg/day for 3months, no erythema and wheals with itching have not developed. Herein we report a case of chronic idiopathic urticaria treated with cyclosporine in a 20-year-old woman.
Subject(s)
Female , Humans , Young Adult , Antibodies , Complement System Proteins , Cyclosporine , Eosinophils , Erythema , Glucocorticoids , Histamine Antagonists , Immunoglobulin E , Pruritus , UrticariaABSTRACT
Solitary myofibroma is a recently described, uncommon neoplasm of superficial soft tissue and presenting as an asymptomatic nodule of the skin, which mainly occurs in adults. It was thought to be the adult counterpart of infantile myofibromatosis. Although it has histopathological similarity to infantile myofibromatosis, it shows a discrete clinicopathological entity compared with infantile form on the basis of its much later onset, superficial location, invariable solitary occurrence and uniformly benign behavior. A 41-year-old female presented a skin lesion on the posterior neck for 1 year, which was a solitary, painless nodule. The excised tumor was diagnosed as myofibroma by light microscopy and immunohistochemistry.